TransCode Therapeutics (NASDAQ: RNAZ) announced it has entered into an exclusive, worldwide, fully paid-up royalty-free license agreement with Unleash Immuno Oncolytics, Inc., obtaining rights to develop three drug candidates — UIO-524, UIO-525 and UIO-526 — including all in-licensed and owned rights held by Unleash. Under the agreement, Unleash will receive a one-time payment of 1,136,364 shares of a new series of non-voting convertible preferred stock, convertible into an equal number of common shares and representing 6.8% of TransCode’s common stock on a fully diluted basis. The lead candidate, UIO-524, is a next-generation oncolytic adenovirus engineered to selectively replicate in malignant cells and cancer-associated stroma, delivering a multi-cytokine immune-activating payload aimed at treating solid tumors, initially targeting muscle-invasive bladder cancer. The company said the addition of UIO-524 expands its oncology pipeline alongside its lead asset, TTX-MC138, which is advancing toward a Phase 2a clinical trial.
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About TransCode Therapeutics
TransCode Therapeutics is a clinical stage company pioneering immuno-oncology and RNA therapeutic treatments for high risk and advanced cancers. The company’s lead therapeutic candidate, TTX-MC138, is focused on treating metastatic tumors that overexpress microRNA-10b, a unique, well-documented biomarker of metastasis. In addition, TransCode’s portfolio includes other first-in-class therapeutic candidates designed to mobilize the immune system to recognize and destroy cancer cells. For more information, visit www.transcodetherapeutics.com.
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