BioMedNewsBreaks — Calidi Biotherapeutics Inc. (NYSE American: CLDI) Reports Promising Preclinical Results for RTNova Virotherapy Platform
Calidi Biotherapeutics (NYSE American: CLDI) announced positive preclinical results for its systemic RTNova platform, demonstrating effective delivery of transient gene therapy payloads to targeted tumors. The tumor-specific virotherapy has shown efficacy across more than 60 tumor cell lines, with a unique vaccinia virus strain enveloped in a human cell membrane providing protection in the bloodstream while targeting distant tumors. In preclinical models, a single dose of the tumor-selective triple knockout (“3KO”) RT virus with an undisclosed immunotherapeutic payload significantly altered the tumor microenvironment, leading to complete tumor eradication in some cases. The findings support the platform’s potential to revolutionize cancer…











