Cancer treatments often involve surgery, radiation and chemotherapy, which may be administered separately or conjointly, in accordance with a patient’s treatment plan. Commonly prescribed potent chemotherapy drugs include cisplatin, which was first discovered in 1965 at Michigan State University. Cisplatin has proven to be an effective chemotherapy medication that can be useful in the treatment of various solid cancers, including lung, ovarian, testicular, head and neck, bladder and stomach.
However, this drug also causes many side effects, including nausea and vomiting; kidney toxicity, which may cause kidney failure in roughly 35% of patients ingesting the drug; and peripheral neuropathy, which causes severe pain in an individual’s feet and hands. Monitoring kidney function is especially crucial for patients on cisplatin, as this reduces the risk of experiencing cisplatin-induced toxicity.
So to help manage these symptoms, researchers have been conducting trials on already available medications in an effort to find some that can mitigate these side effects. Now, a recently conducted study has found that a drug known as istradefylline, which has been approved for use in treating Parkinson’s disease by the FDA, may help alleviate cisplatin’s negative effects.
The study was carried out by a team of researchers from the University of Coimbra in Portugal, the Pasteur Institute of Lille in France, the University of Strasbourg and the University of Lille, in collaboration with Geoffroy Laumet of Michigan State University. Laumet, who is specialized in cisplatin-induced neuropathic pain, is an assistant professor at the institution’s College of Natural Science.
The international team of investigators, together with Laumet, demonstrated through their research that istradefylline not only decreased kidney toxicity but also improved tumor control and relieved peripheral neuropathy; the researchers noted that this drug did so without affecting cisplatin’s effectiveness. Laumet also revealed that the research team had observed istradefylline blocking the effects of adenosine, which is usually released by tumor cells and other cells negatively affected by cisplatin’s toxicity.
It should be noted, however, that while istradefylline (KW6002) is approved for use in humans, the current experiments demonstrating its effectiveness in mitigating the negative effects of cisplatin have only been carried out in animal models thus far. The researchers hope to collaborate with scientists who specialize in human clinical trials soon in an effort to increase their understanding of how the drug works while also testing its safety for use in patients suffering from various cancers who are undergoing cisplatin treatment.
The study’s findings have been published in the “Journal of Clinical Investigation.”
Pain is also another side effect that comes with conventional cancer treatment, and so far, not many solutions are available. Alternative treatments for pain, such as those being developed by India Globalization Capital Inc. (NYSE American: IGC), could offer hope to cancer patients facing chronic pain due to their cancer treatment.
NOTE TO INVESTORS: The latest news and updates relating to India Globalization Capital Inc. (NYSE American: IGC) are available in the company’s newsroom at https://ibn.fm/IGC
About BioMedWire
BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via InvestorWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to millions of social media followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.
To receive SMS text alerts from BioMedWire, text “Biotech” to 888-902-4192 (U.S. Mobile Phones Only)
For more information, please visit https://www.biomedwire.com
Please see full terms of use and disclaimers on the BioMedWire website applicable to all content provided by BMW, wherever published or re-published: http://BMW.fm/Disclaimer
BioMedWire (BMW)
San Francisco, California
www.biomedwire.com
415.949.5050 Office
Editor@BioMedWire.com
BioMedWire is part of the InvestorBrandNetwork.
Scientists have found that keeping circadian rhythms, the variations in body processes during the course…
While many capitalization structures are diluted in the landscape of over-the-counter (“OTC”) markets, Earth Science…
The United States has formally communicated its immediate withdrawal from the World Health Organization (WHO), denying…
Psoriasis is a chronic skin condition that afflicts at least 60 million individuals globally. Nearly 80% of these affected people also…
Researchers at the University of Michigan (U-M) have developed a system that leverages both AI…
LIXTE is developing a first-in-class therapy designed to enhance the effectiveness of existing cancer treatments…