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New LED Therapy Kills Cancer Cells While Sparing Healthy Tissues

Many existing cancer treatments, such as chemotherapy and radiation, don’t distinguish between cancer cells and healthy body cells, and the healthy cells killed alongside cancer cells result in harsh side effects. Researchers are constantly looking for new treatments that are better able to target cancer cells while leaving healthy cells untouched. A new study seems to have uncovered a therapy that could do just that. 

The study, conducted through a collaboration between a team at University of Texas, Austin, and another team at the University of Porto, Portugal, leveraged a combination of using nano-sized tin particles together with LED light. The therapy was able to target cancerous cells and kill them while leaving healthy body cells unaffected. 

Prof. Anne Incorvia, one of the leaders of the Texas-based team that conducted this research, explains that they sought to develop a therapy that was effective, accessible and safe. 

During this preclinical trial, the researchers obtained human colorectal cancer cells and skin cancer cells. They then exposed these malignant cells to the LED light and SnOx nanoflakes (tiny particles of tin). Within half an hour, the treatment eliminated about 92 percent of the skin cancer tissues and 50 percent of the cells with colorectal cancer. Healthy cells were not impacted by this treatment. 

The researchers explained that the tin particles served as a catalyst in a process through which malignant cells were heated using the LED light. This heating process caused the cancer cells to die, and this approach shows promise in killing off remnant cancer cells after a tumor has been surgically removed. By using this method, the likelihood of a tumor regrowing can be greatly reduced, if not eliminated. 

After succeeding in proving their concept, the team is now working to test other materials that can work as catalysts in this therapy. They are also looking more closely into how the heat reaction attains the results observed. Thereafter, they intend to develop devices through which this treatment approach can be used by clinicians managing patients with cancer. 

Their vision is to make their therapy accessible in places where specialized facilities are lacking, and they hope that their approach can be translated into an at-home approach of treating skin cancers. 

Many other teams, such as the R&D team at Calidi Biotherapeutics Inc. (NYSE American: CLDI), are focused on developing cancer treatments that are more effective but don’t come with the side effects that currently characterize the existing options. With time, breakthroughs could be commercialized and patients will benefit from these alternatives. 

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Chris@BMW

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