Study Discovers Genetic Mutation that Makes Solid Tumors Unresponsive to Immunotherapy
While studying why non-human primates aren’t as likely to suffer from certain cancers when compared to humans, UC Davis scientists discovered a genetic mutation that could explain this anomaly. Their findings were published in the Nature Communications journal. This discovery could open the door to the development of more powerful treatments for cancer. The researchers focused on Fas Ligand, an immune protein that helps in attacking tumor cells. This protein is present in both human and non-human primates like chimpanzees. The scientists discovered that in humans, a small mutation makes FasL to be easily deactivated by a tumor-linked enzyme called…