Blocking an Enzyme in Melanoma Patients Could Overcome Resistance to Immunotherapy
Approximately 65% of patients diagnosed with melanoma are unresponsive to immunotherapy. New research suggests that blocking the HPGDS enzyme can be a viable way to improve patients’ response to immunotherapy since the activity of this enzyme contributes to immunotherapy resistance. This approach can also increase immunotherapy response in other types of cancer with similar attributes to those of melanoma. Over the last 10 years, significant advances have been made in leveraging immunotherapy to treat melanoma and other cancers. However, more than half (65%) of melanoma patients don’t respond to immunotherapy. TAMs (tumor-associated macrophages) play a major role in this immunotherapy…











