Prenatal Exposure to Caffeine and High-Fat Diets Heighten Autism Risk in Rodent Models

A new study has found that caffeine exposure during pregnancy and a high-fat diet following delivery considerably heightens the risk of autism-like behaviors, as observed in rodent models. Autism spectrum disorder is a developmental disorder that influences how individuals interact, behave, learn and communicate. Children with this condition may have trouble with social interactions as well as display repetitive behaviors, among other symptoms.

Given that caffeine consumption and high-fat diets are widespread, it is important to understand possible risk factors and develop strategies to prevent the disorder’s development.

For their study, the researchers divided pregnant rats into two groups, one of which was exposed to caffeine during an important period of gestation. The other group acted as the control and received a placebo. Their objective was to make it so that the offspring would either be born with intrauterine growth retardation or normal conditions. Intrauterine growth retardation has been associated with heightened risk for developing autism spectrum disorder.

After their birth, the offspring were also divided into two groups, half of them receiving a high-fat diet while the other were on a standard diet. The researchers’ objective was to evaluate the combined effects of prenatal exposure to caffeine and postnatal dietary habits on the possibility of developing autism-like behaviors.

The researchers determined that female offspring exposed to caffeine demonstrated decreased spatial memory and exploration while males exhibited autism-like behaviors. When both female and male rats exposed to prenatal caffeine were put on a high-fat diet, the researchers observed aggravated autism-like behaviors.

Dan Xu, the author of the study and Wuhan University pharmaceutical sciences professor, stated that the researchers centered on adverse prenatal environments and postnatal secondary impacts because it was often overlooked during research on autism. Xu highlighted that, from the findings, more attention needed to be given to female offspring that had been exposed to adverse environments during the prenatal stages of development. The researchers also observed considerable changes in gut bacteria, which included increased E.coli and a damaged intestinal mucus barrier in the offspring exposed to caffeine and high-fat diets.

They explained that IL-17A, a cytokine that plays a crucial role in allergic responses, was also linked to the increased risk of autism-like behaviors. The cytokine is, as per prior research, a crucial factor in the development of autism spectrum disorder. In the report, Xu noted that the study raised awareness on preventing negative prenatal environmental exposures and healthy childbearing.

These findings give insight into the links between neurodevelopmental disorders, prenatal environmental exposures and diet. The results were published in “Ecotoxicology and Environmental Safety.

With enterprises such as PaxMedica Inc. (NASDAQ: PXMD) working to bring effective autism spectrum disorder treatments onto the market, patients could have a brighter future in the not-so-distant future.

NOTE TO INVESTORS: The latest news and updates relating to PaxMedica Inc. (NASDAQ: PXMD) are available in the company’s newsroom at https://ibn.fm/PXMD

About BioMedWire

BioMedWire (“BMW”) is a specialized communications platform with a focus on the latest developments in the Biotechnology (BioTech), Biomedical Sciences (BioMed) and Life Sciences sectors. It is one of 60+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled recognition and brand awareness.

BMW is where breaking news, insightful content and actionable information converge.

To receive SMS alerts from BioMedWire, “Biotech” to 888-902-4192 (U.S. Mobile Phones Only)

For more information, please visit https://www.BioMedWire.com

Please see full terms of use and disclaimers on the BioMedWire website applicable to all content provided by BMW, wherever published or re-published: https://www.BioMedWire.com/Disclaimer

BioMedWire
San Francisco, CA
www.BioMedWire.com
415.949.5050 Office
Editor@BioMedWire.com

BioMedWire is powered by IBN

Archives

Select A Month

Official NewsWire Relationships

BIO Informa DGE Dynamic Global Events DTC Healthcare Conference Kiasco Reasearch Nexus Conferences Octane

BioMedWire Currently Accepts

Bitcoin

Bitcoin

Bitcoin Cash

Bitcoin Cash

Ethereum

Ethereum

Litecoin

Litecoin

USD Coin

USD Coin

Contact us: 415.949.5050