On March 31, 2022, Silo Pharma (OTCQB: SILO) announced an agreement with contract research organization Frontage Laboratories for an Investigational New Drug (“IND”)-enabling, “Pharmacokinetic Study.” Silo merges traditional therapeutics with psychedelic research to relieve patients suffering from PTSD, Alzheimer’s, Parkinson’s, and other rare neurological disorders. Frontage will study Silo’s Central Nervous System Peptide, SPU-16, “a potential new treatment for multiple sclerosis and other conditions,” and their Joint Homing Peptide, SPU-21, used for treating arthritogenic processes, which, according to Silo Pharma CEO Eric Weisblum, could, “enhance the therapeutic effect of current and future therapeutics while decreasing potential systemic toxicity….They may be used to treat both Central Nervous System and Autoimmune Diseases.”
Pharmacodynamics studies the reactions between drugs and organisms or, simply, the effect of a drug on the body, allowing for a patient’s existing diseases or conditions, their age and other drugs they’re currently taking. Conversely, pharmacokinetics studies the body’s effect on a drug, its “absorption, distribution, metabolism, and excretion,” or the ways and rates a therapeutic enters, courses through, is modified by and finally exits the system.
DMPK (drug metabolism and pharmacokinetics) constitutes a “core discipline in drug development” for assessing drug safety. According to a Frontage Labs factsheet, DMPK studies provide critical research data, assisting therapeutics innovators like Silo to reach important milestones and “decision making during drug discovery and development.” Weisblum says the agreement (with Frontage), “significantly advances our Central Nervous System Peptide, SPU-16, and our Joint Homing Peptide, SPU-21 technologies closer to the clinic.”
Silo Pharma, headquartered in Englewood Cliffs, New Jersey, identifies assets to license and also funds research to better serve patients and advance the health care industry. Recent achievements include a research agreement with Columbia University developing psychedelic therapeutics for Alzheimer’s disease, DEA approval advancing (with Zylo Therapeutics) Z-Pod technology for delivering time-released Ketamine or Psilocybin, a patent for Silo’s Central Nervous System Homing Peptide, granted by the United States Patent and Trademark Office and a sponsored research agreement with UMB evaluating the pharmacokinetics of dexamethasone delivered to arthritic rats via liposomes.
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