Study Finds Alcohol Cravings Get Stronger After Consumption during Withdrawal

Individuals suffering from alcohol or drug addiction usually have certain cues that set off their cravings. Up until now, researchers weren’t sure how and why environmental cues led to more irresistible cravings. Recent findings show that these new cues are stronger than those learned during the early days of an individual’s alcohol use. This discovery could be helpful in the development of new treatments to reduce cravings in individuals with addictions.

Estimates show that more than 14 million individuals in America suffer from alcohol use disorder, which includes various unhealthy drinking behaviors. Similar to other drug addictions, an addiction to alcohol is characterized by cycles of abstinence, relapse and withdrawal.

Cravings are usually triggered by environmental stimuli, which are potent drivers for relapse. For their study, the researchers from Scripps Research Institute used mice models that were dependent on alcohol. Their research objective was to understand if the experience of drinking alcohol repeatedly during withdrawal helped strengthen the learned associations that caused cravings.

Professor Friedbert Weiss, who led the study, stated that while the researchers had known that cravings induced by environmental stimuli usually intensified over time in individuals suffering from severe alcohol use disorder, it wasn’t clear at the neurobiological and behavioral level why this occurred.

The study involved rats that weren’t dependent on alcohol being conditioned to associate an orange scent or anise with alcohol. After this, some of these rats underwent withdrawal cycles, during which they were conditioned to link another scent with the consumption of alcohol. This enabled the researchers to separate the learning that occurred during the nondependent state and during withdrawal.

The researchers then tested the lengths that the rats would go to for alcohol while in the presence of a conditioned smell. They discovered that the rats which had learned to link a certain scent to alcohol would seek out the alcohol when exposed to the scent, noting that the cues the animals picked up during their withdrawal were much stronger at evoking a reaction. The researchers observed that these rats were much more persistent in the presence of this smell.

In addition, the researchers found that the new conditioning also weakened cues that the animal had learned before becoming dependent on alcohol. This discovery opens new possibilities on how addiction and cravings for alcohol can be treated in humans.

Other researchers involved in the study include Mark Mayford, Peter Kufahl and Olga Kozanian. Its findings were reported in the “British Journal of Pharmacology.” The study was supported by funding from the National Institute of Alcohol Abuse and Alcoholism.

With many companies, including Cybin Inc. (NYSE American: CYBN) (NEO: CYBN), engaged in studying how alcohol use disorder and other forms of addiction can be treated more effectively, a breakthrough may not be far from the horizon.

NOTE TO INVESTORS: The latest news and updates relating to Cybin Inc. (NEO: CYBN) (NYSE American: CYBN) are available in the company’s newsroom at https://ibn.fm/CYBN

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via InvestorWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

To receive SMS text alerts from BioMedWire, text “Biotech” to 844-397-5787 (U.S. Mobile Phones Only)

For more information, please visit https://www.biomedwire.com

Please see full terms of use and disclaimers on the BioMedWire website applicable to all content provided by BMW, wherever published or re-published: http://BMW.fm/Disclaimer

BioMedWire (BMW)
San Francisco, California
www.biomedwire.com
415.949.5050 Office
Editor@BioMedWire.com

BioMedWire is part of the InvestorBrandNetwork.

Archives

Select A Month

BioMedWire Currently Accepts

Bitcoin

Bitcoin

Bitcoin Cash

Bitcoin Cash

Ethereum

Ethereum

Litecoin

Litecoin

USD Coin

USD Coin

Contact us: 415.949.5050